5-HTP or 5-Hydroxytryptophan, an amino acid that is the link between tryptophan and the brain chemical serotonin. The 5-HTP used in Hammer Nutrition Appestat is used to reduce cravings for food and promote feelings of well being.

Chromium is a natural trace mineral in human nutrition and is needed for proper metabolism of sugar in humans. It is vital for metabolism of fats and carbohydrates. It helps move blood sugar from the bloodstream into cells to be utilized as energy and turn fats, carbohydrates, and proteins into energy. Chromium helps stimulate fatty acid and cholesterol synthesis, which are needed for brain function and other body processes. It activates numerous enzymes that are required to drive many chemical reactions essential to life. Chromium supplements also improve glucose tolerance in people with Turner's syndrome, a disease associated with glucose intolerance. It is also vital for insulin metabolism. It regulates hunger and decreases cravings.

Hydroxycitric Acid, also known as HCA, is a derivative of citric acid and has a chemical formula 1,2-dihydroxypropane-1,2,3-tricarboxylic acid. This formula suggests that it has two hydroxyl groups attached at carbon 1 and 2 and three carboxylic acid groups attached at carbon number 1, 2 and 3. Studies have indicated its potential as a moderator in lipid metabolism, which means that it can be helpful in weight loss. Clinical studies, however, failed to confirm this. An isomer of HCA known as (2S,3R)-HCA inhibits the enzymes alpha-amylase and alpha-glucosidase leading to reduction of carbohydrate metabolism inside the body. Its link with fat metabolism might be due to the reason that it is a derivative of citric acid which is a key ingredient in the citric acid cycle.

Iodine is an important trace element that plays an important role in the normal growth and development. It essential in maintaining a healthy thyroid gland which, kills harmful germs, makes up its own hormone thyroxin, and gives energy. It assists in maintaining a proper metabolic rate which can influence the blood pressure, heart rate, temperature, and body weight. It is also important in the utilization of calories for energy. It plays an important role in hair, nails and teeth growth. Iodine also aids in the normal growth and maturity of reproductive organs. It also helps prevent still birth or neurocognitive conditions in babies.

Zinc is a metallic chemical element and an essential trace element, whereby only two to four grams of Zinc are found in the human body. There are several biological roles that Zinc plays in humans, including the metabolism of RNA and DNA, gene expression and the regulation of apoptosis. It is deemed vital for proper brain activity and essential in the learning process. It is also critical for the central nervous system, but is also found in muscle, bones, liver, kidneys, eyes and most prominently in the prostate. It is supplied to the body by the ingestion of red meats, particularly beef and lamb, but can also be found in seeds, including sesame and mustard, wheat, beans, whole grains, sunflower seeds and nuts, including almonds.