Indole-3-Carbinol is formed by the breakdown of Glucosinolate glucobrassicin that may be found at comparatively high quantity in cruciferous vegetables. It is the subject of study of current Biomedical research into its probable antioxidant, anticarcinogenic, and anti-atherogenic effects. The researches on indole-3-carbinol have been performed primarily using cultured cells and laboratory animals. Only few, inconclusive and indecisive human studies have been reported. The latest analysis of the biomedical research found that the proof of an association between the intake of cruciferous vegetables and prostate or breast cancer, in human beings is inconsistent and limited. Controlled and randomized trials are required to establish if indole-3-carbinol supplements have health benefits.