Creatine-Fumarate is one of the forms of creatine used by many professional athletes to improve their performance and endurance. Creatine is bound to a molecule of fumarate, a salt or ester of fumaric acid. Creatine is a naturally occurring nitrogenous organic acid in vertebrates that supports in energy supplication in the muscle tissues. It is produced in the body from three amino acids: arginine, methionine and glycine. It is abundantly present in the muscles, brain and both as free creatine and as a phosphate-bound creatine. When supplemented, creatine is beneficial in gaining muscle mass and aids in muscular recovery after strenuous work out. Fumarate, the ester of fumaric acid, is a dicarboxylic acid intermediate in the tricarboxylic acid cycle. It can be derived from tyrosine, phenylalanine and aspartate for the input to the Krebs Cycle, the process of producing usable energy. Having these two moieties combined, they provide dual support in the enhancing muscle mass, endurance and performance. This supplement is contraindicated to preganant and lactating women.

Creatine-Orotate is a compound made up of creatine and orotic acid. The combination of these two is known to improve the performance of athletes and body builders. Creatine helps increase the muscle mass. Orotic acid, on the other hand, increases the supply of Beta Alanine which is converted into carnosine—giving the body an increased and continuous supply of carnosine. Creatine Orotate buffers the muscle cells from the acids that builds up during exercise. This results in increased endurance, more repetitions and longer muscle contraction. It also helps in muscle growth and development by enhancing the formation of creatine phosphate. Creatine-Orotate is a common supplement taken by body builders because it helps in making stronger and bigger muscles.

Creatine-Succinate is an analogue of creatine, an alternative source of energy for muscular tissue. The creatine molecule is attached to the ester of succinic acid, succinate. Supplementary creatine has been used many professional athletes to improve and enhance their performance and endurance. succinic acid, in its ester orm of succinate, plays a vital role in the citric acid (Krebs) cycle. In the electron transport chain, succinic acid can donate electrons and with flavin adenine dinucleotide forms fumarate. With creatine and succinate together, the beneficial effect of one moiety is potentiated by the other. Further, synergistic actions in producing energy can be theoretically claimed. The Food and Drug Administration has regarded this supplement to be safe for human consumption. However, there is a recommended dose and that creatine toxicity is likely that may cause serious kidney and liver damage.

Panax Ginseng- Panax is derived from the Greek word panacea that means “All healing”. It has a wide variety of health benefits. It contains vitamins, essential oils, amino acids, and enzymes that aid the overall health. The main active ingredient of Korean ginseng is ginsenoside which is steroid-like phytochemical that has adaptogenic properties. It helps fight stress and fatigue. It also has anti-carcinogenic property. It also has glycoside that prevents the adrenal glands from producing excessive corticosteroid. Red Korean Ginseng also has panaxtriol that promote anabolic response that is ideal for body builders. It helps in building lean muscles and burn fats for use as fuels. It also helps increase libido and treat sexual dysfunctions.

Piper Nigrum(Black Pepper) or black pepper, which is a common spice, has medicinal properties. It is a tropical plant and India is the largest producer of Piper Nigrum. It possesses anti-bacterial and anti-inflammatory properties. It acts as an antioxidant agent also. Black Pepper contains essential oil, which acts against intestinal flatulence and also stimulates sweating and urination. The essential oil found in Piper Nigrum stimulates stomach cells to produce HCl acid, which helps in digestion. Piper Nigrum also helps in absorption of certain essential micronutrients like coenzyme Q-10, beta-carotene and EGCG. Pepper has its contribution in Ayurvedic medicines also. Pepper seeds are used to prepare sinusitis relieving medicines. It also used for sore throat and dry cough.

Succinate is an ester of succinic acid of Butanedoic Acid. Its name is derived from the word “saccinum” which means amber from which it may be obtained. It occurs naturally in human and in plants. It plays an important role in the Krebs cycle or citric acid cycle that converts fats, carbohydrates, and proteins into carbon dioxide and water to produce energy. It has antioxidant property that protects cells from free radicals. It also has the ability to fight viral and bacterial infections. It stimulates the nerves and benefits the neural system that helps improve awareness, alertness, concentration, focus, and reflexes.